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Biological Sciences
June 13, 2021

Analysis of RNA binding proteins on regulation of tumor suppressor gene PTEN

RBPs play a role in splicing, we want to know if they have a role in the alternative of splicing PTEN, which leads to intron 1 of PTEN not being spliced out. Intron 1 contains an early stop codon which if expressed will stop translation and PTEN will not be translated fully. As PTEN expression is important in breast cancer, we are looking at which RBPs could have a potential effect on the alternative splicing of PTEN, which may lead to breast cancer. This will help us in the diagnosis of the type of breast cancer and target the RBPs for breast cancer treatment to improve prognosis.

 

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  • Author

    Thamanna Muhammed Hashir

  • Advisor

    Ihab Younis

  • Carnegie Mellon University in Qatar

    Education City
    PO Box 24866
    Doha, Qatar
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    +974 4454 8400
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