RBPs play a role in splicing, we want to know if they have a role in the alternative of splicing PTEN, which leads to intron 1 of PTEN not being spliced out. Intron 1 contains an early stop codon which if expressed will stop translation and PTEN will not be translated fully. As PTEN expression is important in breast cancer, we are looking at which RBPs could have a potential effect on the alternative splicing of PTEN, which may lead to breast cancer. This will help us in the diagnosis of the type of breast cancer and target the RBPs for breast cancer treatment to improve prognosis.
